Description

4-(2-Trifluoromethyl-Phenoxy)-Piperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and organic building block. This compound is valued for its unique trifluoromethylphenoxy-piperidine scaffold, which is critical in modern medicinal chemistry for modulating the pharmacokinetic and binding properties of drug candidates. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new chemical entities (NCEs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Research: Used in developing advanced crop protection agents and pesticides, leveraging the biological activity of the piperidine and trifluoromethyl motifs.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways and protein function.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	4-(2-Trifluoromethyl-Phenoxy)-Piperidine Hydrochloride
CAS No.	823782-74-7
Molecular Formula	C12H14F3NO • HCl
Molecular Weight	281.70 g/mol (Free base: 245.24 g/mol)
Synonyms	4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride; 4-(α,α,α-Trifluoro-o-tolyloxy)piperidine hydrochloride; Piperidine, 4-[2-(trifluoromethyl)phenoxy]-, hydrochloride (1:1); 4-(2-Trifluoromethylphenoxy)piperidine HCl; 2-(Piperidin-4-yloxy)benzotrifluoride hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(2-Trifluoromethyl-Phenoxy)-Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.