Description

1,2-Dibenzyl 3-tert-Butyl Piperazine-1,2,3-Tricarboxylate is a specialized, high-purity piperazine derivative used as a critical building block in advanced organic synthesis. Its value lies in its role as a protected intermediate, enabling the precise construction of complex molecules for pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) and antiviral therapeutics.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for creating peptide analogs and mimetics with improved metabolic stability.
• Asymmetric Synthesis: Utilized in chiral pool synthesis and the preparation of enantiomerically pure compounds due to its defined stereochemistry.
• Chemical Biology Probes: Acts as a precursor for labeled compounds or molecular probes used in biochemical and cellular assays.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale under current Good Manufacturing Practices (cGMP).

Basic Information

Product Name	1,2-Dibenzyl 3-tert-Butyl Piperazine-1,2,3-Tricarboxylate
CAS No.	816454-25-8
Molecular Formula	C26H32N2O6
Molecular Weight	468.55 g/mol
Synonyms	1,2-Dibenzyl 3-(tert-Butyl) Piperazine-1,2,3-Tricarboxylate; 3-tert-Butyl 1,2-dibenzyl piperazine-1,2,3-tricarboxylate; 1,2-Dibenzyl 3-tert-butyl piperazine-1,2,3-tricarboxylic acid ester; tert-Butyl 2,3-bis(benzyloxycarbonyl)piperazine-1-carboxylate; 816454-25-8; Piperazine-1,2,3-tricarboxylic acid, 1,2-dibenzyl 3-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 1,2-Dibenzyl 3-tert-Butyl Piperazine-1,2,3-Tricarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.