Description

7-Methyl-5-[(3-Piperazin-1-Ylmethyl)-1,2,4-Oxadiazol-5-Yl-]-2-[4-(Trifluoromethoxy)Benzyl]-2,3-Dihydro-1H-Isoindol-1-One Methanesulphonate is a high-purity, non-racemic pharmaceutical intermediate and research chemical of significant synthetic interest. This compound, with CAS number 802904-66-1, is valued for its complex heterocyclic structure, which incorporates key pharmacophores like the piperazine and oxadiazole rings. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of novel bioactive molecules, particularly within central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potential drug candidates, especially those targeting specific enzyme or receptor pathways.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• Biochemical Tool Compound: Employed in vitro and in vivo to probe biological mechanisms and validate novel therapeutic targets.
• Reference Standard: Serves as an analytical standard for quality control, method development, and regulatory submissions in pharmaceutical R&D.
• Custom Synthesis Starting Material: Provides a sophisticated starting point for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis.

Basic Information

Product Name	7-Methyl-5-[(3-Piperazin-1-Ylmethyl)-1,2,4-Oxadiazol-5-Yl-]-2-[4-(Trifluoromethoxy)Benzyl]-2,3-Dihydro-1H-Isoindol-1-One Methanesulphonate
CAS No.	802904-66-1
Molecular Formula	C26H28F3N5O5S
Molecular Weight	579.59 g/mol
Synonyms	7-Methyl-5-[(3-piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[4-(trifluoromethoxy)benzyl]isoindolin-1-one methanesulfonate; (S)-7-Methyl-5-((3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl))-2-(4-(trifluoromethoxy)benzyl)isoindolin-1-one methanesulfonate; UNII-9J2K30F5Q5; 9J2K30F5Q5; Methanesulfonic acid compound with 7-methyl-5-[3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-3H-isoindol-1-one (1:1); BMS-986169 related compound (methanesulfonate salt).
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for research and development purposes. Identity, purity, and impurity profiles are rigorously verified using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.