Description

1-[(2S)-3-(Acetylthio)-2-Methyl-1-Oxopropyl]-L-Proline Monohydrate is a high-purity chiral intermediate of significant importance in the synthesis of active pharmaceutical ingredients (APIs). Its defined stereochemistry and functional groups make it a critical building block for developing advanced therapeutic compounds. This material is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of complex, stereospecific molecules.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial chiral precursor in the multi-step synthesis of novel APIs, particularly in cardiovascular and metabolic disease research.
• Building Block for Protease Inhibitors: Used in the development of inhibitors targeting specific enzymes, leveraging its proline and thioester moieties.
• Research & Development (R&D): Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Process Chemistry & Scale-Up: Suitable for process development from laboratory to pilot plant scale, supporting route scouting and optimization.
• Reference Standard: Can be utilized as an analytical reference standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	1-[(2S)-3-(Acetylthio)-2-Methyl-1-Oxopropyl]-L-Proline Monohydrate
CAS No.	801293-45-8
Molecular Formula	C11H17NO4S • H2O
Molecular Weight	277.33 g/mol (Anhydrous basis: 259.32 g/mol)
Synonyms	(2S)-1-[(2S)-3-(Acetylthio)-2-Methylpropanoyl]pyrrolidine-2-carboxylic Acid Monohydrate; N-[(2S)-3-(Acetylthio)-2-Methyl-1-Oxopropyl]-L-Proline Monohydrate; L-Proline, 1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]-, monohydrate, (2S)-; Captopril Related Compound; Acetylthio Proline Derivative; ACE Inhibitor Intermediate; S-Acetyl Captopril Precursor
EINECS	Contact for details

Quality Control

Our 1-[(2S)-3-(Acetylthio)-2-Methyl-1-Oxopropyl]-L-Proline Monohydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and specified impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	5.0% - 7.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.