Description

T-Butyl 4-Methanesulfonamidopiperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core functionalized with a Boc-protecting group and a methanesulfonamide moiety. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially those containing a functionalized piperidine scaffold.
• Protease Inhibitor Research: Serves as a precursor in the development of inhibitors for various protease enzymes, which are targets for antiviral and anticancer therapies.
• Kinase Inhibitor Development: Used in constructing molecular libraries for screening and optimizing kinase inhibitors, a major class of oncology and anti-inflammatory drugs.
• Chemical Biology & Probe Synthesis: Employed in the creation of chemical probes for studying biological pathways and target engagement within cells.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Academic & Industrial R&D: Used in research laboratories for method development and exploring new synthetic routes to complex heterocycles.

Basic Information

Product Name	T-Butyl 4-Methanesulfonamidopiperidine-1-Carboxylate
CAS No.	800401-97-2
Molecular Formula	C12H24N2O4S
Molecular Weight	292.40 g/mol
Synonyms	1-Boc-4-(methylsulfonylamino)piperidine; tert-Butyl 4-[(methylsulfonyl)amino]piperidine-1-carboxylate; 4-(Methanesulfonamido)piperidine-1-carboxylic Acid tert-Butyl Ester; 1-N-Boc-4-(methylsulfonamido)piperidine; 4-(Methylsulfonylamino)-1-piperidinecarboxylic Acid tert-Butyl Ester; N-Boc-4-(methylsulfonylamino)piperidine; 800401-97-2; Boc-4-(MsNH)piperidine
EINECS	Contact for details

Quality Control

Every batch of T-Butyl 4-Methanesulfonamidopiperidine-1-Carboxylate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment. Our standard grade typically conforms to a purity of ≥97% (by HPLC), with options for higher purities (≥98%, ≥99%) available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.