Description

3 5-Dimethyoxyphenylmagnesium Chloride is a highly reactive Grignard reagent, a critical organometallic intermediate in fine chemical synthesis. Its value lies in its ability to introduce the 3,5-dimethoxyphenyl moiety into target molecules, enabling the construction of complex aromatic architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity building blocks for coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) with dimethoxyphenyl pharmacophores, such as certain kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides where the dimethoxybenzene structure imparts specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands used in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, including hole-transport layers and luminescent compounds.
• Cross-Coupling Reactions: A vital reagent in Kumada, Negishi, and related cross-coupling methodologies to form carbon-carbon bonds.
• Fine Chemical and Flavor/Fragrance Synthesis: Used to create complex aromatic compounds for high-value chemical and perfumery applications.

Basic Information

Product Name	3 5-Dimethyoxyphenylmagnesium Chloride
CAS No.	89981-17-9
Molecular Formula	C8H9ClMgO2
Molecular Weight	196.91 g/mol
Synonyms	(3,5-Dimethoxyphenyl)magnesium chloride; Magnesium, chloro(3,5-dimethoxyphenyl)-; 3,5-Dimethoxybenzene magnesium chloride; 3,5-Dimethoxyphenyl Grignard reagent; 1-Chloro-3,5-dimethoxybenzene magnesium; 3,5-Dimethoxyphenylmagnesium chloride solution; Grignard reagent 3,5-dimethoxyphenyl-MgCl
EINECS	Contact for details

Quality Control

Our 3 5-Dimethyoxyphenylmagnesium Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and solvent content, to ensure consistency and reliability for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. This product is easily oxidized (store under inert atmosphere) and highly volatile. It must be stored under a dry, inert atmosphere (argon or nitrogen) in a cool, well-ventilated area, away from heat and moisture sources. For prolonged storage, maintaining temperatures at or below 0°C is recommended to preserve reactivity.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Purity (GC/HPLC)	Contact for details
Solvent	Specified (Tetrahydrofuran, Diethyl ether, or Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.