Description

(S)-3-(2-Hydroxyethyl)-2,5-Diketopiperazine is a chiral diketopiperazine derivative, a privileged scaffold in medicinal chemistry and peptide research. This compound matters as a versatile and high-purity building block for the synthesis of complex bioactive molecules and pharmaceutical intermediates. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of protease inhibitors, receptor antagonists, and other active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used as a constrained scaffold to mimic peptide secondary structures, enhancing metabolic stability and bioavailability in novel drug candidates.
• Chemical Biology Probe Development: Employed in creating specialized probes and ligands to study enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis Building Block: Utilized in stereoselective reactions to introduce chiral complexity into target molecules.
• Reference Standard: Provides a high-purity standard for analytical method development and quality control in regulatory submissions.

Basic Information

Product Name	(S)-3-(2-Hydroxyethyl)-2,5-Diketopiperazine
CAS No.	89959-25-1
Molecular Formula	C6H10N2O3
Molecular Weight	158.16 g/mol
Synonyms	(S)-3-(2-Hydroxyethyl)-2,5-piperazinedione; (S)-3-(2-Hydroxyethyl)piperazine-2,5-dione; (S)-HE-DKP; (S)-1,4-Diaza-3-(2-hydroxyethyl)-6-oxobicyclo[3.3.0]octane-2,5-dione; (S)-3-(2-Hydroxyethyl)-2,5-dioxopiperazine; (S)-2,5-Dioxo-3-(2-hydroxyethyl)piperazine
EINECS	Contact for details

Quality Control

Our (S)-3-(2-Hydroxyethyl)-2,5-Diketopiperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.