Description

1-Palmitoyl-2-(4-Carboxybutanoyl)-Sn-Glycero-3-Phosphatidylcholine is a chemically defined, semi-synthetic phospholipid derivative, serving as a critical building block for advanced lipid-based formulations. Its precise molecular structure offers superior batch-to-batch consistency and functional reliability for high-value applications. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced material science sectors who require a high-purity, functionalized lipid for creating targeted delivery systems and biomimetic membranes.

Application

• Liposome & Nanoparticle Formulation: A key functional component for constructing pH-sensitive or targeted drug delivery carriers, leveraging the carboxyl group for surface modification and ligand conjugation.
• Biomembrane Research: Used as a synthetic standard or a functionalized lipid in model membrane studies (e.g., liposomes, supported lipid bilayers) to investigate membrane-protein interactions, permeability, and fusion.
• Diagnostic Reagent Development: Incorporated into diagnostic assays and imaging agents where a stable, derivatizable phospholipid anchor is required for attaching probes or capture molecules.
• Bioconjugation & Surface Chemistry: The terminal carboxylic acid moiety provides a convenient handle for covalent attachment of peptides, antibodies, or polymers via standard carbodiimide (e.g., EDC/NHS) coupling chemistry.
• Cosmetic & Dermal Delivery Systems: Employed in the development of high-performance cosmetic actives and transdermal delivery systems to enhance skin penetration and stability of active ingredients.
• Reference Standard: Serves as a high-purity analytical reference standard for quality control and method development in lipidomics and pharmaceutical analysis.

Basic Information

Product Name	1-Palmitoyl-2-(4-Carboxybutanoyl)-Sn-Glycero-3-Phosphatidylcholine
CAS No.	89947-79-5
Molecular Formula	C35H66NO11P
Molecular Weight	707.88 g/mol
Synonyms	16:0-5:0(COOH) PC; 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine; Glutaryl Phosphatidylcholine; Carboxy-functionalized PC; 1-Hexadecanoyl-2-(4-carboxybutanoyl)-sn-glycero-3-phosphocholine; Functionalized Phospholipid; Anionic Phosphatidylcholine Derivative; PGPC (Palmitoyl-Glutaryl-PhosphatidylCholine)
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-(4-Carboxybutanoyl)-Sn-Glycero-3-Phosphatidylcholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC purity assay, structural confirmation by NMR and MS, and tests for critical impurities to ensure it meets the stringent requirements for research and formulation. Certificates of Analysis (COA) with full traceability are provided to guarantee reproducibility and performance in your applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.