Description

(E,E)-3,5-Di-o-Caffeoylquinic Acid is a specialized polyphenolic compound belonging to the caffeoylquinic acid family, valued for its potent antioxidant and bioactive properties. This high-purity reference standard is critical for research and development in nutraceutical and pharmaceutical applications, where precise chemical identity and activity are paramount. It is primarily sought by analytical laboratories, ingredient manufacturers, and R&D teams in the dietary supplement, functional food, and cosmetic industries for standardization, bioactivity studies, and product formulation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, purity assay, and quantification of related compounds in herbal extracts and finished products.
• Nutraceutical Ingredient R&D: Serves as a key bioactive marker compound in the development of standardized botanical extracts for antioxidant and anti-inflammatory dietary supplements.
• Cosmetic Actives Research: Investigated for its potential skin-protective benefits against oxidative stress in advanced cosmetic and personal care formulations.
• Academic & Clinical Research: Employed in in vitro and in vivo studies to elucidate mechanisms of action related to its biological activities.
• Food & Beverage Analysis: Acts as an analytical standard for quality control in products containing coffee, artichoke, or other natural sources of caffeoylquinic acids.
• Method Development & Validation: Essential for developing and validating robust analytical methods (e.g., HPLC, LC-MS) for complex natural product matrices.

Basic Information

Product Name	(E,E)-3,5-Di-o-Caffeoylquinic Acid
CAS No.	89919-62-0
Molecular Formula	C25H24O12
Molecular Weight	516.45 g/mol
Synonyms	3,5-Di-O-caffeoylquinic acid; 3,5-Dicaffeoylquinic Acid; 3,5-Di-O-caffeoyl-(1S,3R,4S,5R)-quinic acid; Isochlorogenic Acid A; Isochlorogenic acid; Cynarine; Cinarin; 1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3,5-bis(3-(3,4-dihydroxyphenyl)-2-propenoate); (1S,3R,4S,5R)-3-[[(2E)-3-(3,4-Dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexane-1-carboxylic acid 5-(3,4-dihydroxyphenyl)prop-2-enoate
EINECS	Contact for details

Quality Control

Our (E,E)-3,5-Di-o-Caffeoylquinic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and MS for identification, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.