Description

Methyl 2-[(2S)-3-Oxo-2,4,5,6-Tetrahydropyrazin-2-Yl]Acetate is a high-purity chiral intermediate featuring a tetrahydropyrazinone scaffold. This compound is of significant value for its role as a key building block in the synthesis of complex pharmaceutical molecules, particularly those targeting neurological and metabolic pathways. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of new active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and production of peptidomimetics and protease inhibitors.
• API Synthesis: Serves as a key precursor in the multi-step synthesis of complex drug candidates, especially in neurology and metabolic disease research.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop novel therapeutic agents.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block to introduce stereochemical complexity in target molecules.
• Bioconjugation Chemistry: The reactive ester group can be employed for linking pharmacophores or creating prodrugs.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals for advanced material science applications.

Basic Information

Product Name	Methyl 2-[(2S)-3-Oxo-2,4,5,6-Tetrahydropyrazin-2-Yl]Acetate
CAS No.	89852-17-5
Molecular Formula	C7H10N2O3
Molecular Weight	170.17 g/mol
Synonyms	Methyl (2S)-2-(3-oxo-3,4,5,6-tetrahydropyrazin-2-yl)acetate; (S)-Methyl 2-(3-oxo-3,4,5,6-tetrahydropyrazin-2-yl)acetate; 2(1H)-Pyrazinone, 3,4,5,6-tetrahydro-2-(methoxycarbonylmethyl)-, (S)-; (S)-Methyl 2-(3-oxo-3,4,5,6-tetrahydropyrazin-2-yl)ethanoate; L-Pyrazin-2-yl-acetic acid methyl ester (tetrahydro, 3-oxo); Chiral Tetrahydropyrazinone Acetate Ester; 89852-17-5; Contact for EINECS details.

Quality Control

Our Methyl 2-[(2S)-3-Oxo-2,4,5,6-Tetrahydropyrazin-2-Yl]Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.