Description

Protogonyautoxin 4 is a potent neurotoxin belonging to the saxitoxin family, a group of naturally occurring compounds known for their specific action on voltage-gated sodium channels. This high-purity reference standard is critical for advanced analytical and toxicological research, enabling precise detection and quantification of marine biotoxins. It is primarily utilized by research institutions, regulatory agencies, and diagnostic laboratories focused on seafood safety, environmental monitoring, and pharmacological studies of ion channel function.

Application

• Analytical Reference Standard: Primary use as a certified calibrant for the accurate quantification of saxitoxin analogs in complex matrices via HPLC, LC-MS/MS, and other instrumental methods.
• Marine Biotoxin Research: Fundamental research into the biosynthesis, environmental fate, and toxicology of paralytic shellfish poisoning (PSP) toxins.
• Seafood Safety & Regulatory Compliance: Calibration and validation of testing methods to ensure compliance with international regulatory limits for PSP toxins in shellfish.
• Pharmacological Studies: Tool compound for investigating the structure-activity relationships and binding mechanisms of neurotoxins on sodium channels.
• Diagnostic Kit Development: Key component in the development and quality control of immunoassay-based test kits for rapid shellfish toxin screening.
• Environmental Monitoring: Tracking harmful algal blooms (HABs) and studying the ecology of toxin-producing dinoflagellates like *Alexandrium* species.

Basic Information

Product Name	Protogonyautoxin 4
CAS No.	89674-98-6
Molecular Formula	C10H17N7O7
Molecular Weight	347.29 g/mol
Synonyms	GTX4; Gonyautoxin IV; 11-Hydroxysaxitoxin 11-sulfate; 11-Hydroxy-N-sulfosaxitoxin; Protogonyautoxin-IV; PSP Toxin GTX4; Saxitoxin derivative GTX4; (3aS,4R,9aS)-2,6-Diamino-4-(((aminocarbonyl)oxy)methyl)-3a,4,8,9-tetrahydro-1H,10H-pyrrolo(1,2-c)purine-9,9,10-triol 10-sulfate
EINECS	Contact for details

Quality Control

Every batch of Protogonyautoxin 4 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency suitable for use as a certified reference material. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing comprehensive analytical results, including purity by HPLC and structural confirmation, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 5.0 %
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.