Description

Senecivernine n-Oxide is a high-purity pyrrolizidine alkaloid derivative of significant interest in advanced chemical research and development. This compound serves as a critical intermediate and reference standard for the study of natural product chemistry and toxicology. It is primarily utilized by research institutions and pharmaceutical development laboratories focusing on alkaloid biosynthesis, metabolic pathways, and safety profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification and quantification of pyrrolizidine alkaloids and their metabolites in complex matrices.
• Toxicological Research: Employed in studies investigating the hepatotoxicity and metabolic activation pathways of pyrrolizidine alkaloids (PAs).
• Natural Product Chemistry: Serves as a key intermediate or analytical marker in the research of plant-derived compounds, particularly from the *Senecio* genus.
• Biochemical Research: Utilized in enzymatic studies and as a substrate for investigating N-oxidation reactions catalyzed by hepatic enzymes like flavin-containing monooxygenases (FMOs).
• Method Development: Acts as a critical component in developing and validating analytical methods (e.g., HPLC, LC-MS) for the detection of PA N-oxides in herbal products, food, and feed.
• Chemical Synthesis: Used as a building block or precursor in the synthetic modification of alkaloid structures for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Senecivernine n-Oxide
CAS No.	101687-28-9
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	Senecivernine N-oxide; Senecivernine oxide; 12-Hydroxysenecionan-11,16-dione, 13,19-epoxy-3,4-didehydro-15-(hydroxymethyl)-, 4-oxide, (13Z,15E)-; (13Z,15E)-13,19-Epoxy-3,4-didehydro-15-(hydroxymethyl)-12-hydroxysenecionan-11,16-dione 4-oxide; Pyrrolizidine alkaloid N-oxide (Senecivernine); PA N-oxide (Senecivernine)
EINECS	Contact for details

Quality Control

Our Senecivernine n-Oxide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity assessment and structural confirmation, to ensure high consistency and reliability for research applications. A detailed Certificate of Analysis (COA) providing batch-specific data on identity, purity, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.