Description

1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phosphoethanolamine is a specialized lysophospholipid, a key intermediate in the biosynthesis and remodeling of cell membranes. Its unique structure, featuring a single oleoyl chain and a free hydroxyl group, makes it a critical reagent for studying lipid metabolism, membrane asymmetry, and signal transduction pathways. This high-purity compound is essential for researchers and formulators in pharmaceutical development, advanced lipidomics, and the creation of novel liposomal drug delivery systems.

Application

• Lipidomics Research: Used as a standard and substrate for studying phospholipase A2 (PLA2) activity, lipid signaling, and metabolic pathways.
• Liposome & Nanoparticle Formulation: A key component for creating specialized lipid bilayers with tailored fusogenic or targeting properties for drug delivery.
• Biochemical Assay Development: Serves as a critical reagent in enzymatic assays to screen for inhibitors or activators of lipid-modifying enzymes.
• Cell Biology Studies: Employed to investigate membrane dynamics, lipid raft formation, and the role of specific phospholipids in cellular processes.
• Pharmaceutical Intermediates: Acts as a building block for the synthetic preparation of more complex phospholipids and prodrugs.
• Model Membrane Systems: Incorporated into artificial membranes (e.g., supported lipid bilayers) to study biophysical properties and protein-lipid interactions.

Basic Information

Product Name	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phosphoethanolamine
CAS No.	89576-29-4
Molecular Formula	C23H46NO7P
Molecular Weight	479.58 g/mol
Synonyms	1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine; Lyso-PE (18:1); 1-Oleoyl-2-hydroxy-sn-glycero-3-PE; LPE (18:1(9Z)/0:0); (2R)-2-Hydroxy-3-(oleoyloxy)propyl 2-(aminoethyl) hydrogen phosphate; 1-Oleoyl-2-lyso-sn-glycero-3-phosphoethanolamine; Lysophosphatidylethanolamine (18:1); O-LysoPE
EINECS	Contact for details

Quality Control

Our 1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phosphoethanolamine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous in-house specifications and can provide material tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (IR & NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
1-Palmitoyl Isomer (HPLC)	≤ 3.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.