Description

Aprikalim CAS NO 89544-10-5 is a selective potassium channel opener belonging to the cyanoguanidine class of compounds. This compound is of significant interest in pharmacological research due to its role as a vasodilator and cardioprotective agent. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in cardiovascular drug discovery and development.

Application

• Cardiovascular Research: Used as a reference standard and active agent in studies investigating potassium channel function, vasodilation, and myocardial preconditioning.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel cardioprotective and antihypertensive drug candidates.
• Biochemical Assays: Employed in in vitro and in vivo models to study smooth muscle relaxation and cellular signaling pathways involving ATP-sensitive potassium (KATP) channels.
• Reference Standard: Provides a high-purity compound for analytical method development, validation, and quality control in regulatory submissions.

Basic Information

Product Name	Aprikalim
CAS No.	89544-10-5
Molecular Formula	C11H13N5O
Molecular Weight	231.25 g/mol
Synonyms	N-Cyano-N'-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)-N''-1,1-dimethylethylguanidine; BRL 38227; Aprikalim; Potassium channel opener BRL 38227; 6-Cyano-1-[(tert-butylamino)methyl]-1,2,3,4-tetrahydroquinolin-2-one
EINECS	Contact for details

Quality Control

Our Aprikalim is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.