Description

Insulin, Nle(B17)- CAS NO 89468-25-7 is a synthetic insulin analog where the amino acid at position B17 has been substituted with norleucine, a modification that can enhance stability and alter receptor binding kinetics. This engineered peptide is a critical research tool for studying insulin structure-activity relationships and developing novel therapeutic candidates. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on metabolic disease research and peptide drug discovery.

Application

• Pharmaceutical Research & Development: A key reference standard and active material for investigating insulin signaling pathways, receptor interactions, and metabolic functions.
• Structure-Activity Relationship (SAR) Studies: Used to elucidate the impact of specific amino acid substitutions on insulin's biological activity and physical stability.
• Preclinical Development: Serves as a lead compound or intermediate in the development of next-generation insulin analogs with improved pharmacokinetic profiles.
• Biochemical Assay Development: Employed as a critical reagent in the validation of bioanalytical methods, including ELISA, RIA, and cell-based assays for insulin detection.
• Academic Research: Supports fundamental studies in endocrinology, diabetes, and peptide chemistry at universities and research institutes worldwide.
• Quality Control Reference: Can be used as a high-purity comparator in the analysis and quality assurance of insulin-based pharmaceuticals.

Basic Information

Item	Detail
Product Name	Insulin, Nle(B17)- CAS NO 89468-25-7
CAS No.	89468-25-7
Molecular Formula	C257H383N65O77S6
Molecular Weight	~5807.5 g/mol
Synonyms	Norleucine(B17)-Insulin; Insulin B17-Nle; Nle-B17-Insulin; [NleB17]-Insulin; Insulin (human) B17-Nle analog; Insulin analog (B17-Nle); [NorleucineB17]Insulin
EINECS	Contact for details

Quality Control

Our Insulin, Nle(B17)- is produced under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems are designed to meet the rigorous demands of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Peptides (HPLC)	≤ 5.0% total
Water Content (KF)	≤ 5.0%
Peptide Content (UV)	≥ 80.0%
Biological Activity	Assessed by in vitro assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.