Description

Leukotriene E4 Methyl Ester CAS NO 89461-65-4 is a chemically modified derivative of the potent inflammatory mediator Leukotriene E4 (LTE4). This compound is of significant value as a critical analytical standard and research-grade biochemical for studying the leukotriene pathway. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers focused on inflammation, asthma, allergy, and respiratory disease research.

Application

• Biochemical Research Standard: Serves as a primary reference standard for the quantification and identification of leukotriene metabolites in complex biological samples via LC-MS or HPLC.
• Inflammation Pathway Studies: Used in vitro and in vivo research to investigate the role of cysteinyl leukotrienes in inflammatory processes and disease models.
• Pharmaceutical Development: Employed as a key intermediate or reference compound in the discovery and development of leukotriene receptor antagonists and synthesis inhibitors.
• Diagnostic Assay Development: Utilized for the calibration and validation of immunoassays (ELISA) and other diagnostic kits targeting LTE4 and related eicosanoids.
• Metabolite Analysis: Essential for studying the metabolism and pharmacokinetics of leukotriene pathway modulators.

Basic Information

Product Name	Leukotriene E4 Methyl Ester
CAS No.	89461-65-4
Molecular Formula	C24H39NO6S
Molecular Weight	469.64 g/mol
Synonyms	LTE4 Methyl Ester; 5(S)-Hydroxy-6(R)-S-cysteinyl-7,9-trans-11,14-cis-eicosatetraenoic Acid Methyl Ester; (5S,6R)-6-[(1E,3E,5Z,8Z)-1-Carboxy-3,5,8-tetradecatrienyl]-5-hydroxy-2-thia-4-azaoct-7-enoic Acid Methyl Ester; Methyl (5S,6R)-6-[(E,3E,5Z,8Z)-1-carboxy-3,5,8-tetradecatrienyl]-5-hydroxy-4-thia-7,10-diazabicyclo[7.2.0]undec-11-ene-11-carboxylate (various IUPAC forms); LTE4-Me; Cysteinyl Leukotriene E4 Methyl Ester
EINECS	Contact for details

Quality Control

Our Leukotriene E4 Methyl Ester is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive analytical and research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Related Substances (HPLC)	Individual impurity ≤2.0%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.