Description

1,3-Cyclobutanedicarbonyl Dichloride (9Ci) is a high-purity, reactive diacid chloride derivative of cyclobutane-1,3-dicarboxylic acid. This compound serves as a critical bifunctional building block for the synthesis of complex organic molecules, enabling the introduction of the rigid cyclobutane scaffold. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing novel molecular architectures, including constrained peptides, macrocycles, and specialty polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring a conformationally restricted cyclobutane core.
• Peptidomimetic Synthesis: Used to create constrained peptide analogs and macrocyclic compounds for medicinal chemistry and biochemical research.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for producing specialty polyamides, polyesters, and other high-performance polymers with unique thermal and mechanical properties.
• Ligand and Catalyst Development: Building block for synthesizing novel chelating ligands and organometallic complexes used in catalysis.
• Material Science Research: Employed in the development of novel organic frameworks, dendrimers, and other advanced functional materials.
• Chemical Synthesis: Versatile reagent for acyl chloride chemistry, enabling amide and ester bond formation under mild conditions in multi-step synthetic routes.

Basic Information

Product Name	1,3-Cyclobutanedicarbonyl Dichloride (9Ci)
CAS No.	89380-30-3
Molecular Formula	C6H6Cl2O2
Molecular Weight	181.02 g/mol
Synonyms	Cyclobutane-1,3-dicarbonyl dichloride; 1,3-Cyclobutanedicarboxylic acid dichloride; Cyclobutane-1,3-dicarboxylic acid chloride; 1,3-Cyclobutanedicarboxylic dichloride; 1,3-Cyclobutanedicarboxylic acid, dichloride; 1,3-Bis(chlorocarbonyl)cyclobutane; 1,3-Cyclobutanedicarbonyl chloride
EINECS	Contact for details

Quality Control

Our 1,3-Cyclobutanedicarbonyl Dichloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and highly volatile. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Store away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.