Description

Dilinoleoylphosphatidylglycerol CAS NO 89315-60-6 is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylglycerol (PG) esterified with two linoleic acid chains. This compound matters as a critical functional lipid, prized for its role in forming stable, fluid lamellar structures and its anionic charge at physiological pH. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing advanced lipid nanoparticle (LNP) delivery systems, liposomal drug formulations, and as a key component in model membrane studies.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical anionic helper lipid used in mRNA and siRNA delivery systems to enhance stability and cellular uptake.
• Liposomal Drug Delivery: Incorporated into liposome bilayers to impart negative surface charge, improving circulation time and targeting capabilities for anticancer and antifungal therapies.
• Biomimetic Membrane Research: Serves as a key component in creating model membranes (e.g., vesicles, supported lipid bilayers) to study protein-lipid interactions and membrane dynamics.
• Pulmonary Surfactant Mimetics: Investigated for use in synthetic lung surfactant formulations due to its structural similarity to natural surfactant components.
• Cosmetic Actives Carrier: Used in high-end cosmetic formulations for its emulsifying properties and ability to encapsulate and stabilize active ingredients.
• Diagnostic Reagent Preparation: Employed in the development of diagnostic assays and kits that require specific membrane environments.

Basic Information

Product Name	Dilinoleoylphosphatidylglycerol
CAS No.	89315-60-6
Molecular Formula	C47H85O10P
Molecular Weight	841.15 g/mol
Synonyms	1,2-Dilinoleoyl-sn-glycero-3-phospho-(1'-rac-glycerol); PG(18:2/18:2); Phosphatidylglycerol (18:2); DLPg; (9Z,9'Z,12Z,12'Z)-1,2-Bis(octadeca-9,12-dienoyloxy)-3-(phosphonooxy)propyl (2,3-dihydroxypropyl) hydrogen phosphate; 1,2-Di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoglycerol; Dilinoleoyl PG; 1,2-Dilinoleoylphosphatidylglycerol
EINECS	Contact for details

Quality Control

Our Dilinoleoylphosphatidylglycerol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and isomer composition, TLC for lipid profiling, and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical and research applications. Certificates of Analysis (COA) with full traceability are provided for every shipment. Production can be aligned with cGMP guidelines for advanced therapeutic applications upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store unopened vials at -20°C or below under an inert atmosphere (argon or nitrogen). Once opened, use promptly and minimize exposure to air and moisture. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellowish viscous liquid or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC, Area %)	≥ 95.0%
1,2-Dilinoleoyl Isomer Content	≥ 98.0% of total PG
Solvent Residue (GC)	Meets ICH limits
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 5.0 meq/kg
Fatty Acid Profile (GC)	Conforms to linoleic acid standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.