Description

5-Bromo-2-Chloro-3-Methoxy-Pyrazine is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique halogenated pyrazine structure makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides due to its bioactive pyrazine core.
• Material Science Research: Serves as a precursor for creating functionalized heterocyclic compounds used in organic electronic materials and ligands for catalysis.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes and tool compounds for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring complex, halogenated heterocycles.

Basic Information

Product Name	5-Bromo-2-Chloro-3-Methoxy-Pyrazine
CAS No.	89283-94-3
Molecular Formula	C5H4BrClN2O
Molecular Weight	223.46 g/mol
Synonyms	2-Chloro-5-bromo-3-methoxypyrazine; 3-Methoxy-5-bromo-2-chloropyrazine; 5-Bromo-2-chloro-3-methoxypyrazine; Pyrazine, 5-bromo-2-chloro-3-methoxy-; 89283-94-3; 2-Chloro-3-methoxy-5-bromopyrazine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloro-3-Methoxy-Pyrazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.