Description

1-Boc-4-(2-Hydroxyethyl)Piperidine is a versatile and high-purity chemical intermediate featuring a protected amine (Boc) and a terminal hydroxyl group. This bifunctional structure makes it a critical building block for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), especially those targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Peptide Mimetics & PROTACs: Used to construct piperidine-based scaffolds and linkers in advanced therapeutic modalities like proteolysis-targeting chimeras.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Research: Acts as an intermediate in the development of new crop protection agents and pesticides.
• Material Science: Utilized in the creation of specialty polymers and functionalized surfaces requiring specific amine-alcohol chemistry.

Basic Information

Product Name	1-Boc-4-(2-Hydroxyethyl)Piperidine
CAS No.	89151-44-0
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	1-Boc-4-(2-Hydroxyethyl)piperidine; tert-Butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate; 4-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine; N-Boc-4-(2-Hydroxyethyl)piperidine; 1-Boc-4-(β-Hydroxyethyl)piperidine; N-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(2-Hydroxyethyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.