Description

Mpeg12-Mal CAS NO 88504-24-9 is a specialized methoxy polyethylene glycol (mPEG) maleimide derivative, a key functionalized polymer for advanced bioconjugation and material science applications. Its core value lies in providing a heterobifunctional linker that enables the stable, site-specific attachment of biomolecules, nanoparticles, or other functional moieties via the thiol-reactive maleimide group, while the hydrophilic mPEG chain imparts solubility and stealth properties. This compound is essential for researchers and manufacturers in pharmaceutical development (particularly for ADC and PEGylated drug delivery systems), diagnostic reagent production, and the surface modification of nanomaterials to enhance biocompatibility and circulation time.

Application

• Bioconjugation and ADC (Antibody-Drug Conjugate) Linker: Site-specific coupling of cytotoxic drugs, peptides, or proteins to antibodies or other targeting ligands via thiol-maleimide chemistry.
• PEGylation Reagent: Modification of therapeutic proteins, peptides, or oligonucleotides to improve pharmacokinetic profiles, reduce immunogenicity, and enhance solubility.
• Surface Functionalization of Nanoparticles: Creating stealth coatings on liposomes, polymeric nanoparticles, or quantum dots for drug delivery and in vivo imaging applications.
• Crosslinking Agent for Hydrogels: Used in the synthesis of biocompatible hydrogels for tissue engineering and controlled release matrices by reacting with thiolated polymers.
• Diagnostic Assay Development: Conjugation of enzymes, fluorescent dyes, or other detection molecules to antibodies or probes for ELISA, lateral flow assays, and other diagnostic platforms.
• Affinity Chromatography Ligand Coupling: Immobilization of thiol-containing ligands onto activated chromatography resins for protein purification.

Basic Information

Product Name	Mpeg12-Mal
CAS No.	88504-24-9
Molecular Formula	CnH2n+2O(n/12+4) (n~12) *
Molecular Weight	~600-650 g/mol (Average Mn)
Synonyms	mPEG12-Maleimide; Methoxy-PEG12-Maleimide; α-Methoxy-ω-maleimide poly(ethylene glycol); Maleimide-PEG12-OMe; PEG12 Maleimide Ester; Poly(ethylene glycol) methyl ether maleimide (n~12); 2,5-Dioxo-1-pyrrolidinyl ester of methoxy-PEG12-acid
EINECS	Contact for details

* Formula is representative; exact structure depends on PEG chain distribution.

Quality Control

Our Mpeg12-Mal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent functionality, and batch-to-batch reproducibility, meeting the stringent requirements for research and cGMP-grade manufacturing. Certificates of Analysis (COA) detailing purity, molecular weight, functional group assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage under inert atmosphere (argon or nitrogen), please contact us.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Average Molecular Weight (Mn)	600 - 650 Da
PEG Chain Length (n, avg.)	~12
Purity (HPLC)	≥ 95%
Maleimide Functionalization	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO, DMF, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.