Description

(S)-n-Boc-Piperidine-3-Carboxylate Methyl Ester is a high-purity, chiral building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapies. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in process chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug molecules, especially those targeting neurological disorders.
• Peptidomimetic Chemistry: Used in the construction of peptide analogs and protease inhibitors due to its protected amine and ester functionalities.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to introduce stereogenic centers.
• API Development: Integral in the research and scale-up phases for new chemical entities (NCEs) requiring a piperidine scaffold.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for target identification and validation studies.
• Custom Synthesis: A versatile substrate for contract manufacturing and custom synthesis projects requiring high enantiomeric purity.

Basic Information

Product Name	(S)-n-Boc-Piperidine-3-Carboxylate Methyl Ester
CAS No.	88466-76-6
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	(S)-1-Boc-3-Piperidinecarboxylic Acid Methyl Ester; (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic Acid Methyl Ester; Methyl (S)-1-Boc-piperidine-3-carboxylate; (S)-Methyl 1-Boc-piperidine-3-carboxylate; (S)-1-N-Boc-3-Carbomethoxypiperidine; (3S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic Acid Methyl Ester; (S)-tert-Butyl 3-(methoxycarbonyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (S)-n-Boc-Piperidine-3-Carboxylate Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.