Description

Carumonam is a synthetic monobactam antibiotic belonging to the β-lactam class, distinguished by its monocyclic structure. This compound is valued for its potent and specific antibacterial activity against a range of Gram-negative pathogens, including Pseudomonas aeruginosa. It is primarily utilized in pharmaceutical research and development for the synthesis of novel antibacterial agents and as a critical reference standard in analytical and microbiological studies.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel monobactam antibiotics.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of antibiotic products via HPLC, LC-MS, or microbiological assays.
• Microbiological Research: Employed in in vitro studies to investigate bacterial resistance mechanisms and the efficacy of β-lactam compounds.
• Biochemical Studies: Serves as a tool compound to study the interaction with penicillin-binding proteins (PBPs) and β-lactamase enzymes.
• Antibacterial Agent Development: Acts as a core structure for derivatization programs aimed at creating new therapeutic agents with improved pharmacokinetic profiles.

Basic Information

Product Name	Carumonam
CAS No.	87638-04-8
Molecular Formula	C12H14N6O8S2
Molecular Weight	442.41 g/mol
Synonyms	AMA-1080; (Z)-2-[[[(2-Amino-4-thiazolyl)[(1S)-2-carboxy-1-carbamoyl-2-oxoethoxy]imino]acetyl]amino]-2-methylpropanoic acid 1,1-Dioxide; Carumonam disodium; Ro 17-2301; Monobactam derivative AMA-1080; 2-[[(Z)-[1-(2-Amino-1,3-thiazol-4-yl)-2-[(2S)-2-carboxy-2-(carbamoyloxy)-1-oxoethoxy]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid S,S-dioxide
EINECS	Contact for details

Quality Control

Our Carumonam is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency, meeting high-grade standards suitable for research and development. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and microbiological tests is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Meets Ph. Eur. 2.6.12/2.6.13 criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.