Description

Propargyl-Peg5-Alcohol CAS NO 87450-10-0 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a hydroxyl group. This compound is a critical building block in bioconjugation and click chemistry, enabling the site-specific modification of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality linkers for drug delivery systems, diagnostic assays, and functionalized hydrogels.

Application

• Bioconjugation and Click Chemistry: Acts as a versatile linker for coupling biomolecules (e.g., peptides, proteins, oligonucleotides) via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted reactions.
• Pharmaceutical Development: Used in the synthesis of antibody-drug conjugates (ADCs), PEGylated therapeutics, and prodrugs to enhance solubility, stability, and pharmacokinetic profiles.
• Diagnostic Reagents: Serves as a spacer arm in the fabrication of biosensors, immunoassays, and fluorescent probes for improved detection sensitivity.
• Polymer and Material Science: A key monomer or cross-linker for creating functionalized PEG-based hydrogels, smart materials, and surface coatings with tailored properties.
• Nanoparticle Functionalization: Facilitates the surface modification of liposomes, dendrimers, and other nanocarriers for targeted drug delivery applications.
• Chemical Biology Research: Enables the study of biomolecular interactions and cellular processes through selective labeling and tagging strategies.

Basic Information

Item	Details
Product Name	Propargyl-Peg5-Alcohol
CAS No.	87450-10-0
Molecular Formula	C16H30O7
Molecular Weight	334.41 g/mol
Synonyms	5-(2-Propyn-1-yloxy)-3,6,9,12,15-pentaoxapentadecan-1-ol; Propargyl-PEG5-OH; 2-Propyn-1-yl-PEG5-alcohol; Propargyl-O-(CH2CH2O)5-H; 3,6,9,12,15-Pentaoxaheptadec-16-yn-1-ol; Propargyl-Pentaethylene Glycol; Alkyne-PEG5-OH; Propargyl PEG Monomethyl Ether (PEG5)
EINECS	Contact for details

Quality Control

Our Propargyl-Peg5-Alcohol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive applications like bioconjugation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage under an inert atmosphere (e.g., argon or nitrogen), it is recommended to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.