Description

(5R)-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid Sodium Salt is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key building block in the synthesis of carbapenem antibiotics, a critical class of broad-spectrum β-lactam antimicrobials. It is essential for research institutions and manufacturers in the pharmaceutical industry focused on developing and producing next-generation antibiotic therapies.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of carbapenem antibiotics such as meropenem, ertapenem, and doripenem.
• Antibiotic API Synthesis: Serves as the core β-lactam structure for constructing active pharmaceutical ingredients (APIs) with potent antibacterial activity.
• Research & Development: Used in medicinal chemistry research for designing and testing novel β-lactam derivatives and exploring new mechanisms of action.
• Process Chemistry: Employed in scaling up and optimizing manufacturing routes for carbapenem-class drugs in GMP environments.
• Biochemical Studies: Utilized as a standard or reference compound in studies investigating bacterial resistance mechanisms to β-lactam antibiotics.

Basic Information

Product Name	(5R)-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid Sodium Salt
CAS No.	87395-86-6
Molecular Formula	C7H6NNaO3
Molecular Weight	175.12 g/mol
Synonyms	(5R)-7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate sodium salt; Sodium (5R)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; 4-Oxa-2-azabicyclo[3.2.0]hept-3-ene-3-carboxylic acid, 6-oxo-, sodium salt, (2R,5R)-; (2R,5R)-6-Oxo-4-oxa-2-azabicyclo[3.2.0]hept-3-ene-3-carboxylic acid sodium salt; Carbapenem intermediate sodium salt; Meropenem intermediate; 87395-86-6
EINECS	Contact for details

Quality Control

Our (5R)-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid Sodium Salt is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets exacting specifications. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents are provided and can be tailored to meet specific pharmacopeial or internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (5R isomer)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.