Description

1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetic Acid 2-Hydroxy-1-Methylpropyl Ester is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial and pharmaceutical importance. This compound is a key synthetic precursor in the production of advanced pharmaceutical actives, valued for its specific molecular architecture that enables targeted therapeutic effects. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel anti-inflammatory medications.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of proprietary NSAID (Non-Steroidal Anti-Inflammatory Drug) candidates and prodrugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new anti-inflammatory agents.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a direct precursor in multi-step synthesis processes for final API production under GMP conditions.
• Prodrug Synthesis: Utilized in creating ester-based prodrug formulations designed to improve bioavailability or reduce side effects.
• Reference Standard: Sourced by analytical laboratories for use as a high-purity certified reference material (CRM) for method development and quality control.
• Fine Chemical Production: Employed in custom synthesis and scale-up projects for specialized chemical supply chains.

Basic Information

Product Name	1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetic Acid 2-Hydroxy-1-Methylpropyl Ester
CAS No.	87293-45-6
Molecular Formula	C23H24ClNO5
Molecular Weight	429.90 g/mol
Synonyms	Amtolmetin Guacil Ester; Amtolmetin Guacyl; 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid 1-methyl-2-hydroxypropyl ester; Amtolmetin Guacil; UNII-7V3147F5L4; Guacetisal amtolmetin ester; 2-Hydroxy-1-methylpropyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
EINECS	Contact for details

Quality Control

Our 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetic Acid 2-Hydroxy-1-Methylpropyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via spectroscopic methods (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its properties of being light-sensitive and easily oxidized, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.