Description

Indometacin CAS NO 53-86-1 is a potent non-steroidal anti-inflammatory drug (NSAID) belonging to the arylalkanoic acid class, functioning as a cyclooxygenase (COX) inhibitor. This compound is critical for its anti-inflammatory, analgesic, and antipyretic properties, making it a valuable active pharmaceutical ingredient (API). It is primarily required by pharmaceutical manufacturers for the formulation of prescription medications used to treat conditions such as rheumatoid arthritis, osteoarthritis, gout, and other inflammatory disorders.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and generic anti-inflammatory and analgesic medications.
• Rheumatology Treatments: Formulation of drugs for managing symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
• Acute Gout Therapy: Used in medications for the treatment of acute gouty arthritis.
• Analgesic Preparations: Incorporated into formulations for pain relief associated with various inflammatory conditions.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological and biochemical research exploring COX inhibition and inflammation pathways.
• Veterinary Medicine: Potential application in anti-inflammatory treatments for animals.

Basic Information

Product Name	Indometacin
CAS No.	53-86-1
Molecular Formula	C19H16ClNO4
Molecular Weight	357.79 g/mol
Synonyms	Indomethacin; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid; Indocid; Indocin; Indometacine; Artracin; Inteban; Indomee; Confortid
EINECS	200-186-5

Quality Control

Our Indometacin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles and relevant pharmacopoeial standards (USP/EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to yellowish crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.