Description

S-Etodolac CAS NO 87249-11-4 is the single enantiomer of the non-steroidal anti-inflammatory drug (NSAID) Etodolac, specifically the S-(+)-enantiomer. This compound is of significant interest in advanced pharmaceutical research and development due to its targeted pharmacological activity and potential for improved therapeutic profiles with reduced side effects. It is primarily required by pharmaceutical companies and research institutions engaged in the development of novel chiral anti-inflammatory medications, analgesic formulations, and specialized drug delivery systems.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical chiral building block in the synthesis of enantiomerically pure NSAID formulations.
• Pharmacological Research: Used in preclinical and clinical studies to investigate the specific efficacy, metabolism, and safety profile of the S-enantiomer compared to the racemic mixture.
• Chiral Drug Development: A key starting material for developing new single-enantiomer drugs targeting cyclooxygenase-2 (COX-2) with enhanced selectivity.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of Etodolac-based products.
• Formulation Studies: Utilized in developing advanced dosage forms such as controlled-release tablets, transdermal patches, or topical gels.

Basic Information

Product Name	S-Etodolac
CAS No.	87249-11-4
Molecular Formula	C17H21NO3
Molecular Weight	287.35 g/mol
Synonyms	(S)-(+)-Etodolac; (+)-Etodolac; S-(+)-1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid; Dexetodolac; (S)-Etodolac; Etodolac S-enantiomer; (S)-1,8-Diethyl-1,3,4,9-tetrahydro-1H-pyrano[3,4-b]indole-1-acetic acid; AR-1000
EINECS	Contact for details

Quality Control

Our S-Etodolac is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets high-purity standards suitable for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and specific impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.