Description

Sodium Hydrogencarbonate-13C is a stable isotope-labeled analog of sodium bicarbonate, where the carbon atom is the non-radioactive carbon-13 isotope. This compound is essential for advanced analytical research, providing a critical internal standard for precise quantification and metabolic pathway tracing using techniques like mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in pharmacokinetic studies, metabolic research, and high-accuracy environmental analysis.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analysis to ensure accuracy in drug metabolism and pharmacokinetic (DMPK) studies.
• Metabolic Pathway Tracing: Enables the tracking of carbon flow in biological systems for research in biochemistry, plant physiology, and microbiology using 13C-NMR.
• Clinical Diagnostic Assays: Serves as a calibrant or standard in advanced clinical testing methods to improve the precision of biomarker detection.
• Environmental Fate Studies: Applied in research to trace and quantify the degradation pathways of carbon-containing compounds in environmental samples.
• Pharmaceutical Research & Development: Critical for the development and validation of analytical methods for new drug entities, ensuring regulatory compliance.
• Isotope Dilution Analysis: Provides high-accuracy results in the quantification of analytes in complex matrices within food safety and forensic analysis.

Basic Information

Product Name	Sodium Hydrogencarbonate-13C
CAS No.	87081-58-1
Molecular Formula	CH13NaO3
Molecular Weight	84.99 g/mol
Synonyms	Sodium Bicarbonate-13C; Sodium Hydrogen Carbonate-13C; Baking Soda-13C; Carbonic Acid Monosodium Salt-13C; NaH13CO3; [13C]-Sodium Bicarbonate; 13C-Labeled Sodium Bicarbonate; EINECS Contact for details

Quality Control

Our Sodium Hydrogencarbonate-13C is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 13C), chemical purity (by titration or ion chromatography), and absence of critical impurities. We support compliance with relevant pharmacopeial standards where applicable, and specifications can be tailored to meet specific research or method validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent absorption of moisture and carbon dioxide, which can affect purity and stability.

Specification

Item	Specification
Appearance	White crystalline powder
Identification (IR)	Conforms to standard
Assay (Titration)	≥ 99.0%
Isotopic Enrichment (atom % 13C)	≥ 99%
pH (5% solution)	7.5 - 8.5
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm
Chloride (Cl)	≤ 50 ppm
Sulfate (SO4)	≤ 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.