Description

n-(2,4-Dinitrophenyl)-Dl-Leucine is a specialized derivative of the amino acid leucine, modified with a 2,4-dinitrophenyl (DNP) group. This compound is a critical intermediate and reagent in advanced organic synthesis and biochemical research, valued for its role in peptide modification and analytical chemistry. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers involved in proteomics, method development, and the synthesis of novel bioactive molecules.

Application

• Biochemical Research Reagent: Used in peptide sequencing and protein analysis as a derivatizing agent for N-terminal amino acid identification.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex molecules and potential active pharmaceutical ingredients (APIs).
• Proteomics & Analytical Chemistry: Employed in method development for high-performance liquid chromatography (HPLC) and mass spectrometry (MS) applications.
• Organic Synthesis: Acts as a protected or modified leucine derivative in the synthesis of non-natural peptides and chiral compounds.
• Chemical Biology Studies: Utilized to investigate enzyme mechanisms and protein-ligand interactions through specific labeling.
• Reference Standard: Provides a certified material for quality control and analytical method validation in regulated laboratories.

Basic Information

Product Name	n-(2,4-Dinitrophenyl)-Dl-Leucine
CAS No.	10484-03-4
Molecular Formula	C12H15N3O6
Molecular Weight	297.26 g/mol
Synonyms	DL-Leucine, N-(2,4-dinitrophenyl)-; 2,4-Dinitrophenyl-DL-leucine; N-2,4-DNP-DL-leucine; (RS)-2-Amino-4-methylpentanoic acid N-(2,4-dinitrophenyl) derivative; DNP-DL-Leucine; Leucine, N-(2,4-dinitrophenyl)-, DL-; (dl)-N-(2,4-Dinitrophenyl)leucine
EINECS	Contact for details

Quality Control

Our n-(2,4-Dinitrophenyl)-Dl-Leucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, generated using validated analytical methods such as HPLC, NMR, and IR spectroscopy. We are committed to meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.