Description

1-Piperazinamine, 4-(2-Chloro-10,11-Dihydrodibenzo(B,F)Thiepin-10-Yl)- n-(Phenylmethylene)- CAS NO 86758-89-6 is a specialized heterocyclic organic compound featuring a piperazine core fused with a dibenzothiepin moiety. This complex molecular architecture makes it a critical intermediate in advanced synthetic pathways, particularly for the development of active pharmaceutical ingredients (APIs) with targeted neurological and psychotropic effects. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of tricyclic antidepressant and antipsychotic drug candidates.
• Neurological Research: Used in preclinical studies to develop compounds targeting serotonin and dopamine receptors.
• Organic Synthesis: Serves as a versatile precursor for creating complex polycyclic structures in medicinal chemistry.
• Reference Standard: Employed as an analytical standard in quality control and method development for API manufacturing.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis for clinical trial materials.

Basic Information

Item	Details
Product Name	1-Piperazinamine, 4-(2-Chloro-10,11-Dihydrodibenzo(B,F)Thiepin-10-Yl)- n-(Phenylmethylene)-
CAS No.	86758-89-6
Molecular Formula	C25H24ClN3S
Molecular Weight	433.99 g/mol
Synonyms	4-[(2-Chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)]-N-(phenylmethylene)-1-piperazinamine; 4-(2-Chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-N-benzylidene-1-piperazinamine; 86758-89-6; Dibenzo[b,f]thiepin-10-amine derivative; Piperazine, 1-[(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)]-4-(phenylmethylene)amino]-
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided, and we support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.