Description

Frabuprofen CAS NO 86696-88-0 is a non-steroidal anti-inflammatory drug (NSAID) compound belonging to the arylpropionic acid derivative class. It serves as a key pharmaceutical intermediate in the synthesis of active pharmaceutical ingredients (APIs) targeting inflammation and pain management. This compound is primarily utilized by manufacturers in the pharmaceutical and fine chemical industries for research, development, and production of advanced therapeutic formulations.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of non-steroidal anti-inflammatory drug (NSAID) active pharmaceutical ingredients (APIs).
• Research & Development: Serves as a critical reference standard and building block in medicinal chemistry for developing new analgesic and anti-inflammatory agents.
• Fine Chemical Synthesis: Used in multi-step organic synthesis processes to create more complex, target-specific drug molecules.
• Biochemical Research: Employed in studies investigating cyclooxygenase (COX) enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of finished dosage forms.
• Analytical Standard: Provides a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical labs.

Basic Information

Product Name	Frabuprofen
CAS No.	86696-88-0
Molecular Formula	C15H13FO2
Molecular Weight	244.26 g/mol
Synonyms	2-Fluoro-α-methyl-4-biphenylacetic Acid; FR-122047; Frabuprofen; 2-(4-Biphenylyl)-2-fluoro-propionic Acid; (±)-2-Fluoro-α-methyl-4-biphenylacetic Acid; 2-Fluoro-2-methyl-4-phenylbenzenacetic Acid; 4-Biphenylacetic acid, 2-fluoro-α-methyl-; UNII-1Y1I9Q6Z4P
EINECS	Contact for details

Quality Control

Our Frabuprofen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical intermediate applications. We provide full traceability and detailed Certificates of Analysis (COA) that include identity, purity, and impurity profile confirmation via techniques such as HPLC, NMR, and IR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.