Description

4-(Piperazinomethyl)Benzoic Acid, Dihydrochloride is a high-purity, functionalized benzoic acid derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and critical building block for the development of novel pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a piperazine-linked benzoic acid moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Protease Inhibitor Scaffold: Used in the research and development of enzyme inhibitors, where the benzoic acid and piperazine groups provide essential binding motifs.
• Ligand for Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and combinatorial chemistry to create libraries of novel bioactive compounds.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators.
• Bioconjugation & Linker Chemistry: The carboxylic acid and amine functionalities enable its use as a spacer or linker in bioconjugation and the synthesis of antibody-drug conjugates (ADCs).
• Material Science Research: Investigated as a monomer or cross-linking agent for the creation of functional polymers and advanced materials.

Basic Information

Product Name	4-(Piperazinomethyl)Benzoic Acid, Dihydrochloride
CAS No.	86620-70-4
Molecular Formula	C12H18N2O2 • 2HCl
Molecular Weight	307.21 g/mol (as free base: 218.29 g/mol)
Synonyms	4-(Piperazin-1-ylmethyl)benzoic acid dihydrochloride; Benzoic acid, 4-(1-piperazinylmethyl)-, dihydrochloride; 1-[(4-Carboxyphenyl)methyl]piperazine dihydrochloride; 4-(Piperazinomethyl)benzoic acid HCl; p-(Piperazinomethyl)benzoic acid dihydrochloride; Piperazine, 1-[(4-carboxyphenyl)methyl]-, dihydrochloride
EINECS	Contact for details

Quality Control

Our 4-(Piperazinomethyl)Benzoic Acid, Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), residual solvents, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.