Description

Insulin, Pro(B21)- CAS NO 86595-05-3 is a high-purity, synthetic insulin analog designed for advanced research and development applications. This compound is critical for studies focused on insulin structure, receptor binding mechanisms, and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in metabolic disease research and peptide chemistry.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and intermediate in the development of novel insulin analogs and biosimilar products.
• Biochemical Studies: Used to investigate insulin's structure-activity relationships (SAR), folding, and stability under various conditions.
• Receptor Binding Assays: Essential for in vitro studies analyzing the interaction between insulin and its cellular receptors (IR, IGF-1R).
• Metabolic Disease Research: A vital tool for studying diabetes mellitus, insulin resistance, and related metabolic pathways.
• Peptide Chemistry & Synthesis: Acts as a model compound for developing and optimizing peptide synthesis, purification, and analytical methods.
• Quality Control & Analytical Standards: Employed as a certified reference material (CRM) for calibrating analytical instruments like HPLC and MS in QC laboratories.

Basic Information

Product Name	Insulin, Pro(B21)-
CAS No.	86595-05-3
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.9 g/mol
Synonyms	Pro(B21)-Human Insulin; Pro(B21)-Insulin; Insulin (Human) Pro(B21)-; B21-Pro-Insulin; Insulin analog Pro(B21)-; [Pro(B21)]-Insulin; Human Insulin Pro(B21) variant
EINECS	Contact for details

Quality Control

Our Insulin, Pro(B21)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets rigorous standards suitable for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Water Content (KF)	≤ 8.0%
Peptide Content (UV)	≥ 80.0%
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.