Description

Lipoxin D4 is a specialized, endogenously produced eicosanoid signaling molecule, also known as a specialized pro-resolving mediator (SPM). This compound is of significant interest for its potent anti-inflammatory and pro-resolving biological activities, which are distinct from conventional immunosuppression. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and advanced life science sectors for investigating novel therapeutic pathways in inflammation resolution, tissue repair, and immune modulation.

Application

• Biomedical Research: A critical reference standard and tool compound for studying the molecular mechanisms of inflammation resolution, signal transduction, and lipid mediator biology.
• Drug Discovery & Development: Used in high-throughput screening and preclinical studies to identify and validate new targets for treating chronic inflammatory diseases such as arthritis, asthma, and periodontal disease.
• Cell Biology & Immunology: Employed in in vitro and ex vivo assays to modulate macrophage function, neutrophil activity, and cytokine production to understand immune system regulation.
• Biomarker Development: Serves as a precise analytical standard in LC-MS/MS and ELISA methods for quantifying lipoxin levels in biological samples, aiding in diagnostic and prognostic research.
• Advanced Formulation Studies: Investigated for incorporation into novel drug delivery systems aimed at enhancing stability and bioavailability for potential therapeutic applications.

Basic Information

Product Name	Lipoxin D4
CAS No.	85994-54-3
Molecular Formula	C22H32O7
Molecular Weight	408.49 g/mol
Synonyms	LXD4; (7E,9E,11Z,13E)-(5S,6R,15S)-Trihydroxyicosa-7,9,11,13-tetraenoic acid; 5(S),6(R),15(S)-Trihydroxy-7(E),9(E),11(Z),13(E)-eicosatetraenoic acid; 5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid; Aspirin-triggered Lipoxin D4 isomer; ATL-D4 isomer
EINECS	Contact for details

Quality Control

Our Lipoxin D4 is produced and handled under strict quality protocols to ensure the highest standards of purity and batch-to-batch consistency, essential for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and stability data. We adhere to relevant industry guidelines for research-grade biochemicals to support your scientific integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in the original desiccated package.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.