Description

Lipoxin E4 is a specialized pro-resolving lipid mediator (SPM) derived from the lipoxygenase pathway of arachidonic acid metabolism. It plays a critical role in the active resolution of inflammation, promoting tissue repair and homeostasis without immunosuppression. This compound is essential for advanced research in immunology, pharmacology, and the development of novel therapeutic strategies for chronic inflammatory diseases.

Application

• Biomedical Research: A key reference standard and tool compound for studying the molecular mechanisms of inflammation resolution, cellular signaling, and immune modulation.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and target validation for developing new anti-inflammatory and pro-resolving therapeutics.
• In Vitro & In Vivo Studies: Applied in cell culture models and animal studies to investigate its effects on neutrophil recruitment, macrophage phagocytosis, and cytokine regulation.
• Analytical Standard: Serves as a critical standard for method development and validation in analytical techniques like LC-MS/MS and HPLC for quantifying lipid mediators in biological samples.
• Biochemical Pathway Analysis: Utilized to map and understand the complex biosynthesis and metabolic pathways of eicosanoids and specialized pro-resolving mediators.

Basic Information

Product Name	Lipoxin E4
CAS No.	85963-48-0
Molecular Formula	C20H32O5
Molecular Weight	352.47 g/mol
Synonyms	LXA4; Lipoxin A4; (5S,6R,15S)-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic Acid; 5(S),6(R),15(S)-Trihydroxy-7,9,11,13-eicosatetraenoic Acid; 5S,6R,15S-Trihydroxy-7,9,11,13-eicosatetraenoic Acid; (5S,6R,15S)-Trihydroxy-7,9,11,13-eicosatetraenoic Acid; 5,6,15LXA4
EINECS	Contact for details

Quality Control

Our Lipoxin E4 is produced and handled under strict quality protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to cGMP guidelines for manufacturing critical research biochemicals, ensuring traceability and reliability for your scientific work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store unopened vials at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Once opened, the product should be used promptly, and any remaining material should be re-purged with inert gas before resealing.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.