Description

Imipenem is a broad-spectrum, β-lactam carbapenem antibiotic of critical importance in modern medicine. Its primary value lies in its efficacy against a wide range of multi-drug resistant Gram-positive and Gram-negative bacteria, including many strains resistant to other β-lactam antibiotics. This makes it an essential agent for the treatment of severe, life-threatening hospital-acquired infections such as pneumonia, sepsis, and intra-abdominal infections. Pharmaceutical manufacturers and research institutions globally require high-purity Imipenem CAS NO 85960-17-4 for the formulation of injectable drugs and for advanced antimicrobial research.

Application

• Pharmaceutical Active Ingredient: Primary use in the formulation of injectable antibiotic combinations, most commonly with cilastatin, to treat serious infections.
• Hospital Infection Control: Critical for empiric therapy in intensive care units (ICUs) for infections caused by Pseudomonas aeruginosa, Acinetobacter species, and ESBL-producing Enterobacteriaceae.
• Antimicrobial Susceptibility Testing (AST): Used as a reference standard in microbiological laboratories to determine bacterial resistance profiles.
• Research & Development: Serves as a key compound in pharmacological studies, mechanism of action research, and the development of new combination therapies.
• Veterinary Medicine: Employed in specialized veterinary settings for treating severe bacterial infections in animals.

Basic Information

Product Name	Imipenem
CAS No.	85960-17-4
Molecular Formula	C12H17N3O4S•H2O
Molecular Weight	317.36 g/mol (anhydrous basis)
Synonyms	Imipenem Monohydrate; (5R,6S)-3-[[2-(Formimidoylamino)ethyl]thio]-6-[(R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate; N-Formimidoylthienamycin monohydrate; MK-0787; Primaxin (combination product with cilastatin); IMI; IMP
EINECS	Contact for details

Quality Control

Our Imipenem is manufactured and tested to meet stringent pharmaceutical standards. Quality is assured through a comprehensive battery of analytical tests including HPLC for purity and assay, identification by IR and NMR spectroscopy, and rigorous testing for related substances, residual solvents, and microbiological purity. A Certificate of Analysis (COA) detailing all specifications and results is provided with each batch to ensure traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in desiccated conditions after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	4.0% - 6.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	+84° to +92° (c=1 in water)
pH (1% solution)	6.5 - 8.0
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	< 0.17 EU/mg
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.