Description

Indomethacin Farnesil is a specialized farnesyl ester derivative of the non-steroidal anti-inflammatory drug (NSAID) indomethacin. This compound is valued for its potential to enhance drug delivery and modify the pharmacokinetic profile of the parent molecule, offering improved therapeutic windows. It is primarily of interest to pharmaceutical researchers and manufacturers engaged in advanced drug formulation, prodrug development, and targeted delivery systems for anti-inflammatory and analgesic applications.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel prodrug candidates designed for enhanced bioavailability and reduced gastrointestinal side effects.
• Prodrug Development: Utilized in research to create ester-based prodrugs of indomethacin, aiming to improve patient compliance through modified release profiles.
• Topical Formulation Research: Investigated for use in topical gels or creams where the farnesyl moiety may influence skin permeation and local tissue concentration.
• Chemical Biology Studies: Used as a tool compound in studies exploring the role of farnesylation in cellular signaling pathways related to inflammation.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling in related pharmaceutical products.

Basic Information

Product Name	Indomethacin Farnesil
CAS No.	85801-02-1
Molecular Formula	C34H41NO5
Molecular Weight	543.70 g/mol
Synonyms	Indomethacin Farnesyl Ester; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Farnesyl Ester; 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic Acid 3,7,11-Trimethyldodeca-2,6,10-trienyl Ester; Farnesyl Indomethacinate; Indomethacin Farnesylate; Farnesyl 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate
EINECS	Contact for details

Quality Control

Our Indomethacin Farnesil is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards suitable for research and development purposes. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.