Description

Cyclo[D-Leu-D-C4Hyp-n-Methyl-Gly-n-Methyl-L-Leu-L-Ala-n-Methyl-L-Phenyl Gly-n-[(3-Hydroxy-2-Pyridyl)Carbonyl]-L-Thr*-] is a complex, synthetic cyclic peptide derivative of significant interest in advanced pharmaceutical research and development. Its intricate structure, featuring multiple D- and L-amino acids, N-methylations, and a unique 3-hydroxy-2-pyridylcarbonyl moiety, makes it a valuable scaffold for studying peptide conformation, stability, and receptor interaction. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel bioactive molecules, particularly in the fields of oncology, immunology, and metabolic disorders. Its supply demands the highest standards of purity and analytical characterization to ensure reliable and reproducible experimental outcomes.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the discovery and optimization of new therapeutic peptides and peptidomimetics.
• Chemical Biology Studies: Used as a molecular probe to investigate protein-protein interactions, enzyme inhibition, and cellular signaling pathways due to its constrained cyclic structure.
• Structure-Activity Relationship (SAR) Analysis: Provides a core scaffold for medicinal chemists to explore the impact of specific structural modifications on biological activity and pharmacokinetic properties.
• High-Purity Reference Standard: Employed in analytical laboratories for method development, validation, and quality control of related peptide-based compounds.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis, peptide chemistry, and conformational analysis.
• Preclinical Development: Acts as a candidate molecule for in vitro and in vivo efficacy and toxicity profiling in early-stage drug development pipelines.

Basic Information

Product Name	Cyclo[D-Leu-D-C4Hyp-n-Methyl-Gly-n-Methyl-L-Leu-L-Ala-n-Methyl-L-Phenyl Gly-n-[(3-Hydroxy-2-Pyridyl)Carbonyl]-L-Thr*-]
CAS No.	85640-89-7
Molecular Formula	C48H68N8O11
Molecular Weight	933.1 g/mol
Synonyms	Cyclo(Leu-Hyp-Gly-Leu-Ala-Phe-Gly-Thr) derivative; Cyclic Peptide 85640-89-7; L-Thr*, N-[(3-hydroxy-2-pyridinyl)carbonyl]-, cyclic (7->1)-peptide with D-Leu, D-4-hydroxy-L-proline, N-methylglycine, N-methyl-L-leucine, L-alanine, N-methyl-L-phenylalanine and glycine; UNII-7J7Q8E5F5F; 7J7Q8E5F5F; Cyclo[D-leucyl-D-4-hydroxy-L-prolyl-N-methylglycyl-N-methyl-L-leucyl-L-alanyl-N-methyl-L-phenylalanylglycyl-N-[(3-hydroxy-2-pyridinyl)carbonyl]-L-threonine]; [D-Leu-D-Hyp-MeGly-MeLeu-L-Ala-MePhe-Gly-Thr(PyCO)] cyclic peptide
EINECS	Contact for details

Quality Control

Every batch of Cyclo[D-Leu-D-C4Hyp-n-Methyl-Gly-n-Methyl-L-Leu-L-Ala-n-Methyl-L-Phenyl Gly-n-[(3-Hydroxy-2-Pyridyl)Carbonyl]-L-Thr*-] is synthesized and purified under controlled conditions, followed by rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and development applications. Comprehensive Certificates of Analysis (COA) detailing results from HPLC, MS, and NMR analyses are provided with each shipment to support your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.