Description

(4Z)-7-[(1R,2R,3S,5S)-5-([1,1'-Biphenyl]-4-Ylmethoxy)-3-Hydroxy-2-(1-Piperidinyl)Cyclopentyl]-4-Heptenoic Acid Hydrochloride is a high-purity, non-prostanoid prostacyclin (PGI2) receptor agonist, specifically the hydrochloride salt of the active pharmaceutical ingredient. This compound is of significant interest for its potent vasodilatory and antiplatelet properties, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical companies and research institutions focused on cardiovascular therapeutics, thrombosis prevention, and pulmonary arterial hypertension (PAH).

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the production of novel prostacyclin receptor agonists and related therapeutic agents.
• Cardiovascular Research: Used in preclinical and clinical research to study mechanisms of vasodilation, platelet aggregation inhibition, and vascular remodeling.
• Pulmonary Arterial Hypertension (PAH) Drug Development: A vital component in the synthesis pathway for investigational drugs targeting PAH and other pulmonary vascular diseases.
• Biochemical Tool Compound: Employed in vitro and in vivo as a selective agonist to study the IP receptor signaling pathway and its physiological effects.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation of related drug substances.

Basic Information

Product Name	(4Z)-7-[(1R,2R,3S,5S)-5-([1,1'-Biphenyl]-4-Ylmethoxy)-3-Hydroxy-2-(1-Piperidinyl)Cyclopentyl]-4-Heptenoic Acid Hydrochloride
CAS No.	85505-64-2
Molecular Formula	C30H39NO4 · HCl
Molecular Weight	514.10 g/mol
Synonyms	7-[(1R,2R,3S,5S)-5-([1,1'-Biphenyl]-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4Z-heptenoic acid hydrochloride; MRE-269; NS-304; ACT-293987; 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (related analog); PGI2 receptor agonist hydrochloride salt; Prostacyclin receptor agonist intermediate; (4Z)-7-[(1R,2R,3S,5S)-5-([1,1'-Biphenyl]-4-ylmethoxy)-3-hydroxy-2-piperidin-1-ylcyclopentyl]hept-4-enoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (4Z)-7-[(1R,2R,3S,5S)-5-([1,1'-Biphenyl]-4-Ylmethoxy)-3-Hydroxy-2-(1-Piperidinyl)Cyclopentyl]-4-Heptenoic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, and our processes are designed to support development under cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.