Description

(S)-1-Boc-3-Hydroxypiperidine CAS NO 85275-44-1 is a high-purity chiral piperidine derivative, serving as a critical building block in modern organic synthesis. Its value lies in its dual functionality, featuring a Boc-protected amine and a hydroxyl group, which enables precise stereochemical control in complex molecule assembly. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of various drug candidates, including central nervous system (CNS) agents and enzyme inhibitors.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in stereoselective reactions to introduce the (S)-configured piperidine moiety.
• Peptidomimetics & PROTACs: Employed in the construction of peptide mimics and Proteolysis Targeting Chimeras (PROTACs) due to its rigid, functionalized heterocyclic structure.
• Agrochemical Research: Acts as a building block for novel herbicides and fungicides requiring specific stereochemistry for optimal activity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in transition metal catalysis.
• Academic & Process R&D: Utilized in research laboratories for method development and scaling up synthetic routes.

Basic Information

Item	Details
Product Name	(S)-1-Boc-3-Hydroxypiperidine
CAS No.	85275-44-1
Molecular Formula	C10H19NO3
Molecular Weight	201.26 g/mol
Synonyms	(S)-3-Hydroxy-1-(tert-butoxycarbonyl)piperidine; (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine; (S)-N-Boc-3-hydroxypiperidine; (S)-3-Hydroxy-1-Boc-piperidine; (S)-1-Boc-3-piperidinol; tert-Butyl (S)-3-hydroxypiperidine-1-carboxylate; (3S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]piperidin-3-ol; (S)-1-N-Boc-3-hydroxypiperidine
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-3-Hydroxypiperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and chemical assay, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.