Description

(R)-1,2,3,4,10,14B-Hexahydro-2-Methyldibenzo[C,F]Pyrazino[1,2-A]Azepine Maleate is a high-purity, chiral organic compound primarily utilized as a key intermediate in advanced pharmaceutical synthesis. This compound matters for its critical role in the development of active pharmaceutical ingredients (APIs) targeting central nervous system disorders. Pharmaceutical R&D departments and fine chemical manufacturers need this material for producing innovative therapeutics, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel psychoactive and neuroactive drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Asymmetric Synthesis: Serves as a chiral template or precursor in stereoselective chemical reactions.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in API manufacturing.
• Preclinical Studies: Utilized in the preparation of compounds for pharmacological and toxicological evaluation.

Basic Information

Item	Details
Product Name	(R)-1,2,3,4,10,14B-Hexahydro-2-Methyldibenzo[C,F]Pyrazino[1,2-A]Azepine Maleate
CAS No.	85201-39-4
Molecular Formula	C22H24N2O4
Molecular Weight	380.44 g/mol
Synonyms	(R)-Mirtazapine Maleate; (R)-6-Azamianserin Maleate; (R)-1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[1,2-a]pyrido[2,3-c][2]benzazepine Maleate; (R)-2-Methyl-1,2,3,4,10,14b-hexahydro-2H-pyrazino[1,2-a]pyrido[2,3-c][2]benzazepine Maleate; (R)-Org 3770 Maleate; (R)-Mepirzapine Maleate; (R)-Methyl-6-azamianserin Maleate
EINECS	Contact for details

Quality Control

Our (R)-1,2,3,4,10,14B-Hexahydro-2-Methyldibenzo[C,F]Pyrazino[1,2-A]Azepine Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identification by spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccant use and a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.