Description

Brevetoxin Pbtx-3 is a potent marine neurotoxin belonging to the brevetoxin class of polycyclic ether compounds. This high-purity reference standard is critical for analytical research, toxicological studies, and the development of detection methods for harmful algal blooms. It is primarily utilized by research institutions, environmental monitoring agencies, and pharmaceutical developers working on marine biotoxins and neurological pathways. The compound is supplied with full analytical documentation to ensure reliability and reproducibility in sensitive applications.

Application

• Analytical Reference Standard: Primary use as a certified standard for the calibration and validation of analytical methods such as LC-MS/MS and ELISA for detecting brevetoxins in environmental and seafood samples.
• Toxicological Research: Fundamental tool for studying the mechanism of action, dose-response relationships, and cellular effects of neurotoxins on voltage-gated sodium channels.
• Environmental Monitoring: Essential for monitoring programs aimed at detecting and quantifying red tide (Karenia brevis) toxins in water columns and marine organisms to protect public health.
• Diagnostic Development: Used in the research and development of rapid test kits, biosensors, and immunoassays for the on-site detection of marine toxins.
• Pharmacological Studies: Serves as a molecular probe in neuroscience research to investigate ion channel function and to explore potential therapeutic targets.
• Food Safety Testing: Critical for ensuring the safety of shellfish and other seafood by enabling accurate quantification of brevetoxin contamination in compliance with regulatory limits.

Basic Information

Product Name	Brevetoxin Pbtx-3
CAS No.	85079-48-7
Molecular Formula	C50H70O13
Molecular Weight	895.1 g/mol
Synonyms	Brevetoxin-3; PbTx-3; Brevetoxin B; BTX-B; GB-3; (2S)-2-[(1R,2S,5S,6R,7S,9S,11R,14S,15R,17S,18S,20S)-14,15-Dihydroxy-2,6,18-trimethyl-13,16-dioxapentacyclo[12.6.1.0¹,¹¹.0⁵,¹⁷.0⁷,⁹]henicosa-3,10-dien-20-yl]propanoic acid
EINECS	Contact for details

Quality Control

Our Brevetoxin Pbtx-3 is produced under strict quality management systems to ensure the highest standards of purity and identity for research use. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from multiple orthogonal analytical techniques, including HPLC, MS, and NMR. We are committed to providing reference materials that meet the stringent requirements of ISO 17034 (Reference Material Producer) guidelines. Certificates of Analysis are available for review and download upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. The material should be handled in a well-ventilated laboratory setting using appropriate personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	≤ 5.0% total
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.