Description

α-(1-Hydroxy-4-Methylcyclohexyl)-Biphenylacetic Acid, trans-(+)- CAS NO 85045-76-7 is a high-purity, single-isomer organic compound characterized by its specific stereochemistry and functional groups. This compound is a critical chiral intermediate in the synthesis of advanced pharmaceutical active ingredients, where its defined configuration is essential for biological activity and regulatory approval. It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing novel therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the production route for specific enantiomerically pure APIs, ensuring desired efficacy and safety profiles.
• Fine Chemical Research: Employed in academic and industrial R&D for exploring new synthetic pathways and creating novel chemical entities.
• Asymmetric Synthesis Catalyst/Precursor: Can be utilized in the development or as a component of chiral catalysts and ligands for stereoselective reactions.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	α-(1-Hydroxy-4-Methylcyclohexyl)-Biphenylacetic Acid, trans-(+)-
CAS No.	85045-76-7
Molecular Formula	C21H24O3
Molecular Weight	324.42 g/mol
Synonyms	(+)-trans-2-[4-(1-Hydroxy-4-methylcyclohexyl)phenyl]propanoic Acid; (2S)-2-[4-[(1R,4R)-1-Hydroxy-4-methylcyclohexyl]phenyl]propanoic Acid; Dexketoprofen Impurity; Dexketoprofen Related Compound; (S)-(+)-2-(4-Benzoylphenyl)propionic Acid Cyclohexyl Ester Derivative; Ketoprofen Cyclohexyl Derivative; trans-(+)-Trometamol Salt Precursor
EINECS	Contact for details

Quality Control

Our production of α-(1-Hydroxy-4-Methylcyclohexyl)-Biphenylacetic Acid, trans-(+)- adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.