Description

α-(1-Ethyl-1-Hydroxypropyl)-Biphenylacetic Acid, (-)- is a high-purity, single-enantiomer chiral intermediate of significant value in advanced pharmaceutical synthesis. This compound matters because its specific stereochemistry is crucial for developing active pharmaceutical ingredients (APIs) with targeted efficacy and reduced side effects. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and fine chemical industries for the development and manufacture of non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents.

Application

• Key Chiral Intermediate in the synthesis of enantiomerically pure non-steroidal anti-inflammatory drugs (NSAIDs).
• Pharmaceutical Research & Development for novel API pathways requiring specific stereochemical control.
• Fine Chemical Synthesis for building complex molecular architectures in agrochemicals and specialty chemicals.
• Process Chemistry optimization and scale-up for commercial pharmaceutical manufacturing.
• Reference Standard for analytical method development and quality control in regulatory submissions.

Basic Information

Product Name	α-(1-Ethyl-1-Hydroxypropyl)-Biphenylacetic Acid, (-)-
CAS No.	85045-59-6
Molecular Formula	C19H22O3
Molecular Weight	298.38 g/mol
Synonyms	(-)-2-(4-Biphenylyl)-2-hydroxy-2-(1-ethylpropyl)acetic acid; (S)-2-(4-Biphenylyl)-2-hydroxy-2-(1-ethylpropyl)acetic acid; Dexibuprofen Impurity; Dexibuprofen Related Compound; Dexibuprofen Intermediate; (S)-2-(4-Biphenylyl)-2-hydroxy-2-(1-ethylpropyl)ethanoic acid; (S)-2-(Biphenyl-4-yl)-2-hydroxy-2-(1-ethylpropyl)acetic acid
EINECS	Contact for details

Quality Control

Our α-(1-Ethyl-1-Hydroxypropyl)-Biphenylacetic Acid, (-)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity (HPLC), and identification. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and specifications can be aligned with customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-enantiomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.