Description

α-(1-Ethyl-1-Hydroxypropyl)-Biphenylacetic Acid, (+)- CAS NO 85045-58-5 is a high-purity, single-enantiomer chiral compound belonging to the biphenylacetic acid derivative class. This compound serves as a critical pharmaceutical intermediate and a valuable building block in advanced organic synthesis, where its defined stereochemistry is essential for efficacy and safety. It is primarily required by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective chemical reactions to construct complex molecules.
• API Development: Used in research and development for creating new drug candidates, particularly those targeting inflammatory pathways.
• Fine Chemical Production: Serves as a specialized intermediate in the manufacture of high-value, complex organic compounds.
• Biochemical Research: Utilized in studies investigating enzyme-substrate interactions and chiral recognition processes.
• Reference Standard: Acts as an analytical standard for quality control and regulatory compliance in pharmaceutical manufacturing.

Basic Information

Product Name	α-(1-Ethyl-1-Hydroxypropyl)-Biphenylacetic Acid, (+)-
CAS No.	85045-58-5
Molecular Formula	C19H22O3
Molecular Weight	298.38 g/mol
Synonyms	(+)-α-(1-Ethyl-1-hydroxypropyl)-biphenyl-4-acetic acid; (S)-2-(4-Biphenylyl)-2-hydroxy-2-methylbutyric acid (related isomer); Dexibuprofen Impurity; Biphenylacetic Acid Derivative; Chiral Biphenyl Propionic Acid; AR-HPBA; NSC 403169; Dexibuprofen Related Compound A
EINECS	Contact for details

Quality Control

Our production of α-(1-Ethyl-1-Hydroxypropyl)-Biphenylacetic Acid, (+)- adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, to ensure it meets exacting specifications for pharmaceutical-grade intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.