Description

Insulin, Arg(B22)- is a high-purity, chemically modified insulin analog designed for advanced research and development. This product is critical for studies investigating the structure-activity relationships of insulin, particularly the role of the B22 amino acid position in receptor binding and metabolic function. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on diabetes therapeutics and peptide hormone engineering.

Application

• Pharmaceutical Reference Standard: Serves as a critical benchmark in the analytical development and validation of novel insulin analogs and biosimilar products.
• Biochemical Research: Used in structure-function relationship studies to understand the impact of arginine substitution at the B22 position on insulin's biological activity and stability.
• Metabolic Pathway Analysis: A key tool for in vitro and ex vivo research into insulin signaling mechanisms, receptor affinity, and downstream cellular effects.
• Peptide Chemistry & Proteomics: Employed as a model compound in mass spectrometry studies, peptide mapping, and the development of advanced analytical methodologies.
• Drug Discovery Platforms: Integral to high-throughput screening assays and the development of next-generation insulin-based therapies with improved pharmacokinetic profiles.

Basic Information

Product Name	Insulin, Arg(B22)-
CAS No.	85027-35-6
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.9 g/mol
Synonyms	B22-Arginine-Insulin; Arg(B22)-Insulin; [ArgB22]-Insulin; Insulin (human) B22-Arg analog; Insulin analog (B22-Arg); Insulin, Arg-B22-; 85027-35-6; Insulin B22 arginine mutant
EINECS	Contact for details

Quality Control

Our Insulin, Arg(B22)- CAS NO 85027-35-6 is manufactured under strict quality management systems. Each batch is subjected to a comprehensive suite of analytical tests, including HPLC for purity and identity, peptide mapping, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 10.0%
Biological Activity	Assessed by in vitro assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.