Description

6-Methoxy-2-(4-Methoxy Phenyl)-Benzo[B]Thien-3-Yl][4-[2-(1-[Piperidinyl)Ethoxy]Phenyl]Methanone Hydrochloride is a high-purity, non-steroidal selective estrogen receptor modulator (SERM) compound. It is a critical advanced pharmaceutical intermediate used in the research and development of targeted therapeutic agents. This compound is essential for pharmaceutical manufacturers, research institutions, and CROs/CMOs focused on oncology, endocrinology, and women's health applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel Selective Estrogen Receptor Modulators (SERMs) and related therapeutic agents.
• Research & Development: Used as a reference standard and active material in preclinical studies for breast cancer, osteoporosis, and other hormone-related conditions.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core structural component in the multi-step synthesis of complex drug candidates under GMP conditions.
• Biochemical Research: Tool compound for studying estrogen receptor (ER) alpha and beta interactions, mechanism of action, and structure-activity relationships (SAR).
• Contract Manufacturing: Supplied to CMOs for the production of clinical trial materials and commercial API batches.
• Academic Research: Utilized in university and institutional labs for pharmacological and medicinal chemistry research programs.

Basic Information

Item	Details
Product Name	6-Methoxy-2-(4-Methoxy Phenyl)-Benzo[B]Thien-3-Yl][4-[2-(1-[Piperidinyl)Ethoxy]Phenyl]Methanone Hydrochloride
CAS No.	84541-36-6
Molecular Formula	C30H31NO5S · HCl
Molecular Weight	562.10 g/mol (Hydrochloride salt)
Synonyms	LY353381.HCl; Arzoxifene Hydrochloride; Arzoxifene HCl; SERM III; (6-Methoxy-2-(4-methoxyphenyl)benzo[b]thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone hydrochloride; 3-(4-(2-(1-Piperidinyl)ethoxy)benzoyl)-2-(4-methoxyphenyl)-6-methoxybenzo[b]thiophene hydrochloride; Keoxifene analog hydrochloride
EINECS	Contact for details

Quality Control

Our production of 6-Methoxy-2-(4-Methoxy Phenyl)-Benzo[B]Thien-3-Yl][4-[2-(1-[Piperidinyl)Ethoxy]Phenyl]Methanone Hydrochloride adheres to stringent quality systems. Each batch is manufactured under controlled conditions and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) that include HPLC purity, related substances, residual solvents, and other critical parameters. Our quality commitment supports applications from research use to cGMP-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider desiccants or an inert atmosphere. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.