Description

Oxiranecarboxylic Acid, 3-(((3-Methyl-1-((4-(2-Pyrimidinyl)-1-Piperazi Nyl)Carbonyl)Butyl)Amino)Carbonyl)-, Monosodium Salt, (2S-(2-Alpha,3-B Eta(R*)))- is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of complex, biologically active molecules, particularly those targeting specific enzymatic pathways. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or cardiovascular targets.
• Protease Inhibitor Research: Serves as a core structural component in the design and development of protease inhibitor candidates.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Bioconjugation & Prodrug Synthesis: The reactive epoxide and functional groups allow for its use in creating targeted drug conjugates or prodrug formulations.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	Oxiranecarboxylic Acid, 3-(((3-Methyl-1-((4-(2-Pyrimidinyl)-1-Piperazi Nyl)Carbonyl)Butyl)Amino)Carbonyl)-, Monosodium Salt, (2S-(2-Alpha,3-B Eta(R*)))-
CAS No.	84518-86-5
Molecular Formula	C20H27N5O5Na
Molecular Weight	448.46 g/mol
Synonyms	1-[(2S,3R)-3-({[(2S)-4-Methyl-1-oxo-1-{[4-(pyrimidin-2-yl)piperazin-1-yl]amino}pentan-2-yl]amino}carbonyl)oxiran-2-yl]formic acid sodium salt; (2S,3R)-Epoxysuccinic acid derivative monosodium salt; N-[(2S,3R)-3-Carboxyoxiran-2-yl]carbonyl-L-leucyl-N'-[4-(pyrimidin-2-yl)piperazin-1-yl]urea monosodium salt; A potent protease inhibitor intermediate; Sodium (2S,3R)-1-[(2S)-2-({[(2S,3R)-3-carboxyoxiran-2-yl]formyl}amino)-4-methylpentanoyl]-4-(pyrimidin-2-yl)piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our Oxiranecarboxylic Acid derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable for the production of pharmaceutical intermediates, and our quality protocols are designed to meet the exacting standards of global R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.