Description

Pyrazinecarbonyl Chloride Monohydrochloride is a versatile and highly reactive acid chloride derivative used as a key building block in advanced organic synthesis. Its primary value lies in enabling the efficient introduction of the pyrazinecarbonyl moiety, a critical structural motif in various high-value compounds. This intermediate is essential for research and production in the pharmaceutical and agrochemical industries, particularly for the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs containing heterocyclic amide or ester functionalities.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the pyrazine ring system imparts specific biological activity.
• Peptide & Protein Modification: Serves as a coupling agent or acylating agent for modifying amino acids, peptides, or proteins to study structure-activity relationships.
• Material Science Research: Employed in the creation of novel polymers, ligands for catalysis, and organic electronic materials due to its reactive acid chloride group.
• Chemical Biology Probes: Facilitates the labeling and study of biological molecules through the formation of stable covalent bonds.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	Pyrazinecarbonyl Chloride Monohydrochloride
CAS No.	84473-64-3
Molecular Formula	C5H4Cl2N2O
Molecular Weight	178.00 g/mol
Synonyms	Pyrazine-2-carbonyl chloride hydrochloride; 2-Pyrazinecarbonyl chloride hydrochloride; Pyrazinoic acid chloride hydrochloride; Pyrazinecarboxylic acid chloride hydrochloride; 2-Carbamoylpyrazine chloride hydrochloride; Pyrazinoyl chloride hydrochloride; Pz-COCl·HCl
EINECS	Contact for details

Quality Control

Our Pyrazinecarbonyl Chloride Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (DMF, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.